The use of cultured bone marrow cells for autologous transplantation in patients with acute myeloblastic leukemia.
نویسندگان
چکیده
The permissive or inductive environment provided by bone marrow stromal cells in long-term cultures allows the persistent proliferation and differentiation of haemopoietic stem and progenitor cells [1]. Cells harvested from cultures of murine bone marrow can reconstitute the haemopoietic system when transplanted into lethally irradiated mice [2]. If bone marrow heavily infiltrated with leukaemic cells is cultured using similar conditions, the leukaemic blast cells become undetectable within 1 week, and the cultured marrow can then be used to rescue
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عنوان ژورنال:
- Haematology and blood transfusion
دوره 31 شماره
صفحات -
تاریخ انتشار 1987